Yes, but you won’t have full power if you’re splitting the flow in to 2 zones at the same time.
How the system is designed in a Marquis Signature is that you have 3 zones on each pump. The 3 zones allow you to isolate all the power in to the HK (red jets) on your lower back, upper back, or feet. There is a zone on each of the “Z3” controls that allows you to have jets running in every seat, so if you have a group of 5-6 people using the spa, every soaker will have jets, but in this setting you won’t have the high powered HK (red jets) running.
There is a setting on the Reward where you can have all of the power running to your lower back from 1 pump and all of the power running to your feet at the same time from the other pump. You should try and find that setting when you are soaking by yourself, you will like it!